After more than 12,000 years, dire wolves are back. On April 8, 2025, Colossal Biosciences announced the birth of three healthy dire wolf pups, marking the world’s first successful de-extinction of a large vertebrate predator. This groundbreaking achievement combines cutting-edge genetic engineering with ancient DNA to resurrect one of North America’s most iconic Ice Age predators.
The science behind bringing back an extinct species
Colossal’s de-extinction process began with extracting
